Evidence-Based Appraisal of Antireflux Fundoplication

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Evidence-based appraisal of antireflux fundoplication.

OBJECTIVE To highlight the current available evidence in antireflux surgery through a systematic review of randomized controlled trials (RCTs). SUMMARY BACKGROUND DATA Laparoscopic fundoplication is currently suggested as the gold standard for the surgical treatment of gastroesophageal reflux disease, but many controversies are still open concerning the influence of some technical details on ...

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Mechanisms underlying the antireflux action of fundoplication.

The effect of fundoplication on patterns of gastro-oesophageal reflux and the underlying motor mechanisms were investigated in 18 patients with symptomatic reflux. Oesophageal motility and pH were recorded concurrently after a standard meal. Studies were performed preoperatively and from 5 to 27 months after surgery. Fundoplication virtually eliminated reflux in all but three patients. Control ...

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Long-term antireflux medication use following pediatric Nissen fundoplication.

HYPOTHESIS Nissen fundoplication decreases the use of antireflux medications. DESIGN Retrospective cohort study using discharge abstract data and pharmacy data. SETTING Twelve regional Kaiser Permanente hospitals in southern California. PATIENTS Three hundred forty-two patients underwent Nissen fundoplication. INTERVENTION Nissen fundoplication. MAIN OUTCOME MEASURE Use of antireflux ...

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Dysphagia after antireflux fundoplication: endoscopic, radiological and manometric evaluation.

BACKGROUND The transient dysphagia after fundoplication is common and most often disappears until six weeks postoperatively. AIM Analyze a group of patients who presented late and persistent dysphagia postoperatively. METHODS Forty-one patients after Nissen fundoplication, 14 male and 27 female, mean age 48 year, were evaluated based on medical history, esophagogastroduodenoscopy, contrast ...

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Therapy of gastroesophageal reflux: evidence-based approach to antireflux surgery.

BACKGROUND Due to the chronic, relapsing nature of gastroesophageal reflux disease, lifelong therapeutic options have to be considered and recommended in many patients. Accordingly, surgical repair has to be evaluated based on modern, evidence-based methodologies. METHODS A careful review has been carried out of the relevant surgical literature also including trials incorporating direct compa...

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ژورنال

عنوان ژورنال: Annals of Surgery

سال: 2004

ISSN: 0003-4932

DOI: 10.1097/01.sla.0000114225.46280.fe